Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

The magnitude of the host immune response can be regulated by either stimulatory or inhibitory immune checkpoint molecules.Receptor-ligand binding between inhibitory molecules is often exploited by tumours to suppress anti-tumour immune responses.Immune checkpoint inhibitors that block these inhibitory interactions can relieve T-cells from negative

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